Evelo Biosciences Inc (NASDAQ:EVLO) has announced the results of immunological biomarker analyses from its previously reported Phase 2 trial of orally-dosed EDP1815 in mild and moderate psoriasis.
- Treatment with EDP1815 led to a statistically significant reduction in the release of cytokines compared to placebo: IL-6 (p=0.0003), IL-8 (p=0.0007), and TNF (p=0.0037).
- The effect of EDP1815 was observed by the deep tail of reduced cytokine production on the left of the distribution for each cytokine, absent in the placebo groups.
- There was no worsening compared to placebo on the right of the distributions, resulting in the overall significant difference between EDP1815 and placebo.
- Related: Evelo Biosciences Psoriasis Candidate Shows Benefit In Mid-Stage Study.
- In addition, skin biopsies of active lesions were taken from a subset of six patients who received EDP1815 and achieved at least a 50% improvement in their Psoriasis Area and Severity Index score.
- RNAseq analysis showed reductions in transcript levels for psoriasis-relevant cytokines interleukin 23 (IL-23), interleukin 12b (IL-12b), and interleukin 17 (IL-17).
- Six-month follow-up efficacy and safety data from the Phase 2 trial will be available later this quarter.
- Price Action: EVLO shares are trading 3.91% higher at $4.52 premarket on the last check Monday.
